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Jazz Pipeline
PRE-CLINICAL
Oxybate
Once Nightly Formulation

CombiPlex
Solid tumors candidate

CombiPlex
Hem/Onc exploratory activities

Recombinant Crisantaspase-HLE2
ALL/other hematological malignancies

Recombinant Pegaspargase1
Hematological malignancies

Defibrotide
Exploratory activities

Exosome NRAS candidate2
Hematological malignancies

Exosome STAT3 candidate2
Hematological malignancies

Exosome-based candidates2
Solid tumors/ Hematological malignancies

Pan-RAF Inhibitor Program
RAF & RAS mutant tumors

PHASE 1
CPX-351 + gemtuzumab3
R/R AML or HMA Failure
MDS

CPX-351 + venetoclax
Low Intensity Therapy for first-line, unfit AML (Phase 1b)

CPX-3513
Low Intensity Dosing for higher risk MDS

IMGN6321
CD123+ Hematological malignancies5

PHASE 2
Defibrotide
Prevention of aGvHD

Defibrotide4
Treatment of TA-TMA

Defibrotide4
Prevention of CAR-T associated neurotoxicity

CPX-351 + venetoclax3
de novo or R/R AML

CPX-3516
HR-MDS

CPX-3516
R/R AML (COG)

CPX-3514,6
Newly diagnosed older adults with HR-AML

CPX-351 + venetoclax4,6
HR-AML

JZP-458 (Recombinant Crisantaspase)4
ALL (Phase 2/3)

PHASE 3
JZP-258
Cataplexy & EDS in narcolepsy

JZP-258
Idiopathic hypersomnia

Defibrotide
Prevention of VOD

CPX-3516
AML or HR-MDS (AML19)

CPX-3516
AML or HR-MDS (AML18)

CPX-3516
Newly diagnosed adults with standard- and HR-AML

CPX-3514,6
Newly diagnosed pediatric patients

REGULATORY
Solriamfetol EU
EDS in OSA and Narcolepsy

Sleep
Hematology / Oncology
1Opt-in opportunity
2Partnered collaboration
3Jazz & MD Anderson Cancer Center collaboration study
4Planned
5Including AML and BPDCN
6Cooperative group study

Jazz Pharmaceuticals is a global biopharmaceutical company dedicated to bringing life-changing medicines to people with limited or no options, so they can live their lives more fully.
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Clinical Trials

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By unlocking biopharmaceutical discoveries to develop novel medicines, we are giving thousands of people around the world the opportunity to redefine what’s possible.