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Jazz Pipeline
PRE-CLINICAL
JZP-324
Oxybate once-nightly formulation

CombiPlex
Hem/Onc exploratory activities

JZP-341 (Long-acting Erwinia asparaginase)2
ALL/other hematological malignancies

Recombinant Pegaspargase1
Hematological malignancies

Pan-RAF Inhibitor program
RAF & RAS mutant tumors

Exosome targets (NRAS, STAT3 and 3 others)2
Hematological malignancies/solid tumors

Defibrotide
Exploratory activities

PHASE 1
CPX-351
Low Intensity Dosing for higher risk MDS3

CPX-351 + other approved therapies
  • R/R AML or HMA Failure MDS3
  • First-line, fit AML (Phase 1b)
  • Low Intensity Therapy for first-line, unfit AML (Phase 1b)
IMGN6321
  • R/R CD123+ Hematological malignancies
  • +/- venetoclax/azacitidine in CD123+ AML (Phase 1b/2)

PHASE 2
JZP-3854
Essential tremor (Phase 2b)

Defibrotide
  • Prevention of aGvHD
  • Prevention of CAR-T associated neurotoxicity
CPX-351
  • HR-MDS (EMSCO)5
  • Newly diagnosed older adults with HR-AML4,5
CPX-351 + venetoclax
de novo or R/R AML3

PHASE 3
JZP-258
Idiopathic hypersomnia

JZP-458 (recombinant Erwinia asparaginase)
ALL/LBL (pivotal Phase 2/3)

Lurbinectedin6
Relapsed SCLC (ATLANTIS)

CPX-351
  • AML or HR-MDS >60 yrs (AML18)5
  • AML or HR-MDS >18 yrs (AML19)5
  • Newly diagnosed adults with standard- and HR-AML (AMLSG)5
  • Newly diagnosed pediatric patients with AML (COG)4,5

REGULATORY
JZP-258
Cataplexy & EDS in narcolepsy

Neuroscience
Hematology/Oncology
1Opt-in opportunity
2Partnered collaboration
3Jazz & MD Anderson Cancer Center collaboration study
4Planned
5Cooperative group study
6Exclusive U.S. license

Jazz Pharmaceuticals is a global biopharmaceutical company dedicated to bringing life-changing medicines to people with limited or no options, so they can live their lives more fully.
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By unlocking biopharmaceutical discoveries to develop novel medicines, we are giving thousands of people around the world the opportunity to redefine what’s possible.